Recent publications

Repeated exposure to chlorpyrifos is associated with a dose-dependent chronic neurobehavioral deficit in adult rats

Ribeiro ACR, Hawkins E, Jahr FM, McClay JL, Deshpande LS

Neurotoxicology 90:172-183

Epigenetics in drug disposition & drug therapy: symposium report of the 24th North American meeting of the International Society for the Study of Xenobiotics (ISSX)

Maldonato BJ, Vergara AG, Yadav J, Glass SM, Paragas EM, Li D, Lazarus P, McClay JL, Ning B, Daly AK, Russell LE

Drug Metab Rev 54(3): 318-330

Epigenetic regulation of drug metabolism in aging

McClay JL

Aging (Albany NY) 13(13): 16898-16899

Histone acetylation at the sulfotransferase 1a1 gene is associated with its hepatic expression in normal aging

Kronfol MM, Abudahab S, Dozmorov MG, Jahr FM, Halquist MS, McRae M, Wijesinghe DS, Price ET, Slattum PW, McClay JL

Pharmacogenet Genomics 31(9): 207-214

Epigenetic histone acetylation and Bdnf dysregulation in the hippocampus of rats exposed to repeated, low-dose diisopropylfluorophosphate

Ribeiro ACR, Jahr FM, Hawkins E, Kronfol MM, Younis RM, McClay JL, Deshpande LS

Life Sciences 281: 119765

Review and Consensus on Pharmacogenomic Testing in Psychiatry

Bousman CA, Bengesser SA, Aitchison KJ, Amare AT, Aschauer H, Baune BT, Behroozi Asl B, Bishop JR, Burmeister, M, Chaumette B, Chen LS, Cordner ZA, Deckert J, Degenhardt F, DeLisi LE, Folkersen L, Kennedy JL, Klein TE, McClay JL, McMahon F, Musil R, Sangkuhl K, Saccone NL, Stowe RM, Tan EC, Tiwari AK, Zai CC, Zai GC, Zhang J, Gaedigk A, Müller DJ

Pharmacopsychiatry 54 (1): 5-17

Molecular mechanisms for the antidepressant-like effects of a low-dose ketamine treatment in a DFP-based rat model for Gulf War Illness

Ribeiro AC, Zhu J, Kronfol MM, Jahr FM, Younis RM, Hawkins E, McClay JL, Deshpande LS

Neurotoxicology 80: 52-59

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver

Kronfol MM, Jahr FM, Dozmorov MG, Phansalkar P, Xie LY, Aberg KA, McRae M, Price ET, Slattum PW, Gerk PM, McClay JL

Geroscience 42 (3), 819-832

Cell-type specific differences in antiretroviral penetration and the effects of HIV-1 Tat and morphine among primary human brain endothelial cells, astrocytes, pericytes, and microglia

Patel SH, Ismaiel OA, Mylott WR, Yuan M, McClay JL, Paris JJ, Hauser KF, McRae M

Neuroscience Letters 712: 134475

The ANKS1B gene and its associated phenotypes: Focus on CNS drug response

Younis RM, Taylor RM, Beardsley PM, McClay JL

Pharmacogenomics 20 (9): 669-684

Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk.

Xia H, Jahr FM, Kim NK, Xie L, Shabalin AA, Bryois J, Sweet DH, Kronfol MM, Palasuberniam P, McRae M, Riley BP, Sullivan PF, van den Oord EJ, McClay JL

Human Molecular Genetics 27 (18): 3246-3256

Effects of HIV-1 Tat and methamphetamine on blood-brain barrier integrity and function in vitro

Patel SH, Leibrand CR, Palasubramaniam P, Couraud P-O, Weksler B, Jahr FM, McClay JL, Hauser KF, McRae M.

Antimicrobial Agents and Chemotherapy  61 (12): e01307-17

Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence

Clark SL, McClay JL, Adkins DE, Kumar G, Aberg KA, Nerella S, Xie L, Collins AL, Crowley JJ, Quackenbush CR, Hilliard CE, Shabalin AA, Vrieze SI, Peterson RE, Copeland WE, Silberg JL, McGue M, Maes H, Iacono WG, Sullivan PF, Costello EJ, van den Oord EJ

Alcoholism: Clinical and Experimental Research   41 (4): 711-718

The role of epigenomics in personalized medicine.

Kronfol MM, Dozmorov MG, Huang R, Slattum PW, McClay JL.

Expert Review in Precision Medicine and Drug Development 2 (1): 33-45

Initial characterization of behavior and ketamine response in a mouse knockout of the post-synaptic effector gene Anks1b.

Enga R, Rice AC, Weller P, Subler M, Lee D, Hall CP, Windle JJ, Beardsley PM, van den Oord EJ, McClay JL.

Neuroscience Letters  641: 26-32 

Deep sequencing of three loci implicated in large-scale GWAS smoking meta-analyses.

Clark SL, McClay JL, Adkins DE, Aberg KA, Kumar G, Nerella S, Xie LY, Collins AL, Crowley JJ, Quakenbush C, Hillard C, Gao G, Peterson R, Copeland W, Silberg J, Maes H, Sullivan PF, Costello EJ, van den Oord EJ.

Nicotine & Tobacco Research 18 (5): 626-31

Neurochemical metabolomics reveals disruption to sphingolipid metabolism following chronic haloperidol administration.

McClay JL, Vunck SA, Batman AM, Crowley JJ, Vann RE, Beardsley PM, van den Oord EJ.

Journal of Neuroimmune Pharmacology  10 (3): 425-434.

High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.

McClay JL, Shabalin AA, Dozmorov MG, Adkins DE, Kumar G, Nerella S, Clark SL, Bergen SE, Hultman CM, Magnusson PKE, Sullivan PF, Aberg KA, van den Oord EJ. 

Genome Biology  16 (1): 291.