Evaluating the role of ANKS1B in mediating second generation antipsychotic drug efficacy

Agency: VCU Center for Clinical and Translational Research (CCTR) Endowment and NIH/NCATS UL1TR000058

Project number: CCTR Pilot

Principal Investigator: JL McClay

Period: Apr 2016 - Sep 2017

We will test behavioral response to antipsychotics in a mouse knockout for Anks1b, which encodes an effector of the post-synaptic density, and evaluate mechanisms of response via proteomics.