Evaluating the role of ANKS1B in mediating second generation antipsychotic drug efficacy

Agency: VCU Center for Clinical and Translational Research (CCTR) Endowment and NIH/NCATS UL1TR000058

Project number: CCTR Pilot

Principal Investigator: JL McClay

Period: Apr 2016 - Sep 2017

We will test behavioral response to antipsychotics in a mouse knockout for Anks1b, which encodes an effector of the post-synaptic density, and evaluate mechanisms of response via proteomics.

A longitudinal methylome study to detect biomarkers predicting MDD trajectories

Agency: NIH/NIMH R01

Project number: MH099110

Principal Investigator: EJ van den Oord

Period: Sep 2013 – Jun 2018

Our overarching goal is to identify methylation markers in peripheral blood samples associated with clinical major depressive disorder (MDD) trajectories over a six year time period.

Functional characterization of pathways regulated by schizophrenia gene TCF4

Agency: NIH/NIMH R21

Project number: MH099419

Principal Investigator: JL McClay

Period: Sep 2012 - Jun 2014

We aim to identify the gene network(s) regulated by transcription factor 4 using ChIP-seq and to test the network(s) in genetic, methylation and expression datasets for association with schizophrenia. 

Cis & Trans-Data Integration to Find Mechanisms Causing Psychiatric Disorders

Agency: NIH/NIMH R01

Project number: MH097283

Principal Investigator: EJ van den Oord, VCU / PF Sullivan, UNC-Chapel Hill, PIs

Period: Apr 2012 – Mar 2015

We propose to integrate results from a voluminous collection of large-scale datasets to identify disease mechanisms for schizophrenia, bipolar disorder, major depression, and autism.

Evaluating the genetic, epigenetic and miRNA control of global gene expression in the Stanley Medical Research Institute (SMRI) postmortem brain sample

Agency: SMRI Research Grant

Project number: GR#08R-1959

Principal Investigator: VI Vladimirov

Period: Nov 2010 – Nov 2012

We will generate a molecular brain expression map to better understand the interactions between miRNAs and their targets and how these interactions are modulated by eQTLs and methylation.

Functional Characterization of Three Novel Genes Associated With Antipsychotic Response in the CATIE Study

Agency: NARSAD Young Investigator Award

Project number:

Principal Investigator: JL McClay

Period: Jan 2010 – Dec 2011

Bioinformatics and targeted functional methods will be used to better understand genes associated with olanzapine or risperidone response.

Whole genome profiling to detect schizophrenia methylation markers

Agency: NIH/NIMH RC2

Project number: MH089996

Principal Investigator: EJ van den Oord

Period: Oct 2009 – Sep 2011

We will compare genome-wide methylation status in 1500 schizophrenia cases and controls using next-generation sequencing and follow up findings in an independent sample.

A genome-wide association study to detect genes for schizophrenia

Agency: NIH/NIMH R01

Project number: MH078069

Principal Investigator: EJ van den Oord, PI, VCU / PF Sullivan, UNC-Chapel Hill, PIs

Period: Jan 2008 – Dec 2011

The goal of this project is to replicate the main findings of genome-wide association study using ~16,000 SNPs in sample of 5,000 cases and controls + sample of 5,500 subjects from 1,400 families.